AC/AP Reversal
Last modified by Hussein Abdallah on 2025/05/26 03:33
Reversal Agents x Drugs
| Reversal Agent | Contents / Mechanism | Drugs reversed | Labs affected | NOTES |
|---|---|---|---|---|
| Vitamin K | ||||
| FFP | tPA (2nd line) | #2 option for tPA reversal | ||
| 4 Factor PCC (K Centra) | Xarelto (rivaroxaban) | |||
| Cryoprecipitate | fibrinogen, vWF, fibronectin Factor 7, AT-III | tPA | Fibrinogen | tPA depletes fibrinogen (contained in cryo) |
| Protamine | ||||
| TXA | tPA (2nd line) | #2 option for tPA reversal |
Mechanism of Common Anticoagulants
Xarelto = Factor 10a inhibitor